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Pheniramine Maleate

Cat. No. M2935
Pheniramine Maleate Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 35  USD35 In stock
100mg USD 50  USD50 In stock
200mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.

Chemical Information
Molecular Weight 356.42
Formula C16H20N2.C4H4O4
CAS Number 132-20-7
Solubility (25°C) Water 40 mg/mL
DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ercan Yuvanc, et al. Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

[2] Aastha Gupta, et al. Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption

[3] Ozgur Ozmen, et al. Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

[4] K Venugopal, et al. Pheniramine Maleate-Induced Rhabdomyolysis and Aki: Is it Fatal?

[5] Kerem Karaman, et al. Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy

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