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PF-4840154

Cat. No. M14283

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PF-4840154 Structure
Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

Chemical Information
Molecular Weight 466.62
CAS Number 1332708-14-1
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Clara Hoebart, et al. No functional TRPA1 in cardiomyocytes

[2] Amrita Samanta, et al. Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition

[3] Thomas Ryckmans, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel

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Keywords: PF-4840154 supplier, TRP Channel, inhibitors, activators

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