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PF-07059013 

Cat. No. M29637

All AbMole products are for research use only, cannot be used for human consumption.

PF-07059013  Structure

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Quality Control & Documentation
Biological Activity

PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research.

Chemical Information
Molecular Weight 365.36
Formula C19H16FN5O2
CAS Number 2435610-93-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Min Xu, et al. AAPS J. A Pharmacometrics Model to Characterize a New Type of Target-Mediated Drug Disposition (TMDD) - Nonlinear Pharmacokinetics of Small-Molecule PF-07059013 Mediated By Its High-capacity Pharmacological Target Hemoglobin With Positive Cooperative Binding

[2] Kelly M Knee, et al. Am J Hematol. PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease

[3] Ariamala Gopalsamy, et al. J Med Chem. PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

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Keywords: PF-07059013  supplier, inhibitors, activators

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