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PF-06843195

Cat. No. M21296

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PF-06843195 Structure
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Biological Activity

PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts.The Ki of PF-06843195 acting on PI3Kα and PI3Kδ is less than 0.018 nM and 0.28 nM, respectively.PF-06843195 has a significant inhibitory effect on PI3K/mTOR signaling pathway and had a long-lasting anti-tumor effect.

Chemical Information
Molecular Weight 498.46
Formula C20H25F3N8O4
CAS Number 2067281-51-8
Solubility (25°C) DMSO : 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hengmiao Cheng, et al. J Med Chem. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-06843195 supplier, PI3K, inhibitors, activators

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