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PF-06826647, also known as Tyk2-IN-8, is a selective and orally administered tyrosine kinase 2 (TYK2) inhibitor, with IC50 of 17 nM. PF-06826647 inhibits a panel of 231 kinases at non-physiologically conditions for each kinase Km showed 21 non-JAK kinases with >50% at 1 μM dose. PF-06826647 inhibits ear swelling in the imiquimod-induced skin inflammation model.
| Molecular Weight | 383.41 |
| Formula | C20H17N9 |
| CAS Number | 2127109-84-4 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related JAK Products |
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| Deuruxolitinib
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| A-005
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| Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
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