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PF-05198007 

Cat. No. M28007

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PF-05198007  Structure

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Quality Control & Documentation
Biological Activity

PF-05198007 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771.

Chemical Information
Molecular Weight 533.91
Formula C19H12ClF4N5O3S2
CAS Number 1235406-19-5
Form Solid
Solubility (25°C) DMSO 150 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] George Goodwin, et al. Pain. Examination of the contribution of Nav1.7 to axonal propagation in nociceptors

[2] Aristos J Alexandrou, et al. PLoS One. Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-05198007  supplier, Sodium Channel, inhibitors, activators

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