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PF-04937319

Cat. No. M8096

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PF-04937319 Structure

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Quality Control & Documentation
Biological Activity

PF-04937319 is a glucokinase activator with an EC50 value of 174 nM. PF-04937319 was found to improve glycemic control in adults with type 2 diabetes when used in conjunction with metformin.

Chemical Information
Molecular Weight 432.43
Formula C22H20N6O4
CAS Number 1245603-92-2
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hidetaka Kamimura, et al. A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

[2] William S Denney, et al. Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study

[3] Hidetaka Kamimura, et al. Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

[4] N B Amin, et al. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes

[5] Raman Sharma, et al. Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator

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Keywords: PF-04937319 supplier, inhibitors, activators

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