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PF-04577806 is a potent, selective and ATP competitive PKC inhibitor. PF-04577806 shows potent inhibitory activity towards PKCα, PKCβI, PKCβII, PKCγ, and PKCθ with IC50s of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. PF-04577806 can reverse retinal vascular leakage in diabetic rats.
| Molecular Weight | 495.62 |
| Formula | C26H37N7O3 |
| CAS Number | 1072100-81-2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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