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Perisulfakinin

Cat. No. M43215
Perisulfakinin Structure
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Biological Activity

Perisulfakinin, a satiety signaling neuropeptide, inhibits the activity of central neurons promoting general activity.

Chemical Information
Molecular Weight 1523.61
Formula C64H86N18O22S2
CAS Number 125131-58-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dieter Wicher et al. Front Cell Neurosci. The satiety signaling neuropeptide perisulfakinin inhibits the activity of central neurons promoting general activity

[2] H J Matthews et al. Arch Insect Biochem Physiol. In vitro and in vivo effects of myo-active peptides on larvae of the tomato moth Lacanobia oleracea and the cotton leaf worm Spodoptera littoralis (Lepidoptera; Noctuidae)

[3] Aaron T Haselton et al. J Insect Physiol. The effects of Calliphora vomitoria Tachykinin-I and the FMRFamide-related peptide Perisulfakinin on female Phormia regina crop contractions, in vitro

[4] E Horn et al. Acta Astronaut. Crickets in space

[5] J A Veenstra et al. Histochem Cell Biol. Immunohistological localization of regulatory peptides in the midgut of the female mosquito Aedes aegypti

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Keywords: Perisulfakinin supplier, inhibitors, activators

 
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