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Penitrem A

Cat. No. M7109

All AbMole products are for research use only, cannot be used for human consumption.

Penitrem A Structure

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Quality Control & Documentation
Biological Activity

Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively). Displays no effect on native delayed rectifier K+ and KATP currents, or cloned KV1.5 channels. Blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo.

Chemical Information
Molecular Weight 634.2
Formula C37H44ClNO6
CAS Number 12627-35-9
Solubility (25°C) DMSO 6.34 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Escande, et al. Biochem Biophys Res Commun. The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.

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Keywords: Penitrem A supplier, inhibitors, activators

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