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Pectolinarigenin

Cat. No. M4748
Pectolinarigenin Structure
Size Price Availability Quantity
10mg USD 171  USD190 In stock
20mg USD 324  USD360 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Pectolinarigenin strongly inhibited COX-2-mediated PGE2 and 5-LOX-mediated LT production at >1 microM. Pectolinarigenin possess anti-inflammatory activity and may inhibit eicosanoid formation in inflammatory lesions.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 314.29
Formula C17H14O6
CAS Number 520-12-7
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.
Lim H, et al. Biol Pharm Bull. 2008 Nov;31(11):2063-7. PMID: 18981574.

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  Catalog
Abmole Inhibitor Catalog 2017




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