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PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader. PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells.
| Molecular Weight | 508.23 |
| Formula | C18H16F3IN2O4 |
| CAS Number | 2581116-22-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | -20°C, protect from light |
| Related Ligands for Target Protein for PROTAC Products |
|---|
| AP1867-2-(carboxymethoxy)
AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. |
| BTK ligand 1
BTK ligand 1 is a ligand targeting Bruton’s tyrosine kinase (Btk). |
| TSPO ligand-1
TSPO ligand-1 is the ligand of AUTAC4 that can be used in the synthesis of PROTACs. |
| PROTAC PTK6 ligand-1
PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation. |
| PROTAC BRD4 ligand-2
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. |
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