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PD-1/PD-L1-IN-NP19 is a PD-1/PD-L1 inhibitor, with an IC50 of 12.5 nM for human PD-1/PD-L1 interaction. PD-1/PD-L1-IN-NP19 could activate the immune microenvironment in tumor, which may contribute to its antitumor effects.
| Molecular Weight | 555.06 |
| Formula | C33H31ClN2O4 |
| CAS Number | 2377916-66-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 2 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Chinmoy Ghosh, et al. J Cancer. A snapshot of the PD-1/PD-L1 pathway
[3] Yanyan Han, et al. Am J Cancer Res. PD-1/PD-L1 pathway: current researches in cancer
[4] Nyanbol Kuol, et al. Immunotherapy. PD-1/PD-L1 in disease
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