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PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 exhibits anti-tumor activity and inhibits early B-cell receptor (BCR) signaling, can be used to B-cell malignancies research.
| Molecular Weight | 537.51 |
| Formula | C24H30Cl2N6O2S |
| CAS Number | 1215011-08-7 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Erwan Beauchamp, et al. Nat Commun. Targeting N-myristoylation for therapy of B-cell lymphomas
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