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Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity.
| Molecular Weight | 1107.26 |
| CAS Number | 396091-76-2 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | -20°C, protect from light, sealed |
[3] Lynnette K Nieman. Update in the medical therapy of Cushing's disease
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