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Paltusotine

Cat. No. M29328

All AbMole products are for research use only, cannot be used for human consumption.

Paltusotine Structure
Synonym:

CRN00808

Size Price Availability Quantity
1mg USD 225  USD225 In stock
5mg USD 550  USD550 In stock
10mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

Paltusotine (CRN00808) is an orally active, nonpeptide selective somatostatin type 2 (SST2) receptor agonist. Paltusotine has the potential for maintaining GH and IGF-1 levels after depot somatostatin receptor ligand therapy.

Chemical Information
Molecular Weight 456.49
Formula C27H22F2N4O
CAS Number 2172870-89-0
Form Solid
Solubility (25°C) DMSO 20 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jian Zhao, et al. ACS Med Chem Lett. Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

[2] David S McLaren, et al. J Clin Endocrinol Metab. Paltusotine, a Novel Oral Somatostatin Receptor Ligand in the Management of Acromegaly

[3] Monica R Gadelha, et al. J Clin Endocrinol Metab. ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly

[4] Ajay Madan, et al. Pituitary. Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

[5] Monica R Gadelha, et al. J Clin Endocrinol Metab. The Future of Somatostatin Receptor Ligands in Acromegaly

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Keywords: Paltusotine, CRN00808 supplier, Somatostatin Receptor, inhibitors, activators

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