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Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats.
| Molecular Weight | 454.99 |
| CAS Number | 2469274-58-4 |
| Solubility (25°C) | DMSO 50 mg/mL Water 7.14 mg/mL |
| Storage | 2-8°C, dry, sealed |
[1] M Bays, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials
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