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Oxymatrine has been shown to exhibit anti‑inflammatory, antiviral, and anticancer properties. Oxymatrine significantly inhibited the proliferation of prostate cancer cells in a time‑ and dose‑dependent manner. Oxymatrine treatment may induce prostate cancer cell apoptosis in a dose‑dependent manner. In vivo analysis demonstrated that oxymatrine inhibited tumor growth following subcutaneous inoculation of prostate cancer cells into nude mice. Oxymatrine exerts anti-inflammatory properties in LPS-stimulated macrophages by down-regulating the TLR4/NF-κB pathway. Oxymatrine effectively suppressed the phosphorylation of EGFR (Tyr845), and EGFR was the target of oxymatrine. Oxymatrine could be a strong immunomodulator, influence TLR9 signaling transduction, and synergistically improve the immune efficacy of the TLR9 ligand against CHB.
| Molecular Weight | 264.37 |
| Formula | C15H24N2O2 |
| CAS Number | 16837-52-8 |
| Solubility (25°C) | DMSO 53mg/ml Water 53mg/ml Ethanol 53mg/ml |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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