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Oxyclozanide

Cat. No. M9461
Oxyclozanide Structure
Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Biological Activity

Oxyclozanide is a salicylanilide anthelmintic compound, which acts by uncoupling oxidative phosphorylation in flukes.

Chemical Information
Molecular Weight 401.46
Formula C13H6Cl5NO3
CAS Number 2277-92-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] David Garca-Dios, et al. Efficacy of Oxyclozanide and Closantel against Rumen Flukes (Paramphistomidae) in Naturally Infected Sheep

[2] Weiwei Wang, et al. Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

[3] Rafael Ayerbe-Algaba, et al. The anthelmintic oxyclozanide restores the activity of colistin against colistin-resistant Gram-negative bacilli

[4] Jili Zhang, et al. Determination and pharmacokinetics study of oxyclozanide suspension in cattle by LC-MS/MS

[5] Michael M Maiden, et al. The ionophore oxyclozanide enhances tobramycin killing of Pseudomonas aeruginosa biofilms by permeabilizing cells and depolarizing the membrane potential

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