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Oxolamine Citrate

Cat. No. M20795
Oxolamine Citrate Structure
Synonym:

SKF-9976 citrate, AF-438 citrate

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Biological Activity

Oxolamine (SKF-9976, AF-438) citrate, a cough suppressant, is an inhibitor of CYP2B1/2. Oxolamine citrate also exhibits anti-inflammatory effect.

Chemical Information
Molecular Weight 437.44
Formula C20H27N3O8
CAS Number 1949-20-8
Solubility (25°C) DMSO 87 mg/mL
Water 43 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] L CARRATU. Gazz Med Ital. [Oxolamine citrate in geriatric practice]

[2] S Dahlgren, et al. Acta Pharmacol Toxicol (Copenh). The effect of oxolamine citrate on experimentally produced inflammation in the respiratory organs

[3] T Dalhamn. Am Rev Respir Dis. The anticiliostatic effect of cigarettes treated with oxolamine citrate

[4] J McEwen, et al. Med J Aust. Hallucinations in children caused by oxolamine citrate

[5] L Kirilmaz, et al. J Microencapsul. Sustained-release dosage form of oxolamine citrate: preparation and release kinetics

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  Catalog
Abmole Inhibitor Catalog




Keywords: Oxolamine Citrate, SKF-9976 citrate, AF-438 citrate supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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