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Dehydro Nifedipine is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is an antianginal and antihypertensive agent. Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
| Molecular Weight | 344.32 |
| Formula | C17H16N2O6 |
| CAS Number | 67035-22-7 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 6α-Hydroxy Paclitaxel
6α-Hydroxy Paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy Paclitaxel (6-Hydroxytaxol) retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. |
| Casein (from bovine milk)
Casein is a phosphorus-containing complex protein with α-casein and β-casein as its main components. Casein is an orally active phosphoprotein that can be separated into various electrophoretic components, such as α2-Casein, κ-Casein, β-casein, and γ-casein. Casein can be used in biochemical research, to formulate biological culture media, and as a thickener, emulsifier and stabiliser. |
| Palmitic acid-13C16
Palmitic acid-13C16 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. |
| Methionine sulfoximine
Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine. |
| L-Glutamine-15N2
L-Glutamine-15N2 is the 15N-labeled L-Glutamine. L-Glutamine is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells. |
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