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Oxcarbazepine

Cat. No. M2264
Oxcarbazepine Structure
Synonym:

Trileptal

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 115  USD115 In stock
100mg USD 170  USD170 In stock
500mg USD 310  USD310 In stock
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Quality Control & Documentation
Biological Activity

Oxcarbazepine is an anticonvulsant and mood-stabilizing compound used primarily in the treatment of epilepsy. Oxcarbazepine protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Oxcarbazepine is also used to treat anxiety and mood disorders, and benign motor tics.

Chemical Information
Molecular Weight 252.27
Formula C15H12N2O2
CAS Number 28721-07-5
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ahmad Beydoun, et al. Current role of carbamazepine and oxcarbazepine in the management of epilepsy

[2] Jamir Pitton Rissardo, et al. Carbamazepine-, Oxcarbazepine-, Eslicarbazepine-Associated Movement Disorder: A Literature Review

[3] Muke Zhou, et al. Oxcarbazepine for neuropathic pain

[4] Ahmad Beydoun, et al. Oxcarbazepine

[5] No authors listed. Lancet. Oxcarbazepine

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Keywords: Oxcarbazepine, Trileptal supplier, Sodium Channel, inhibitors, activators


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