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Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.
| Molecular Weight | 426.55 |
| Formula | C27H30N4O |
| CAS Number | 60607-34-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 250 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] K Hayashi, et al. Cochrane Database Syst Rev. Oxatomide for stable asthma in adults and children
[3] C Möller, et al. Allergy. Oxatomide in seasonal rhinoconjunctivitis
[4] No authors listed. Drug Ther Bull. Oxatomide--a new H1-antihistamine
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