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Ouabain octahydrate

Cat. No. M7980
Ouabain octahydrate Structure
Synonym:

Acocantherine; G-Strophanthin

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Biological Activity

Ouabain Octahydrate is an inhibitor of Na+/K+-ATPase, used for the treatment of congestive heart failure. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity. Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD.

In vivo, Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS.

Chemical Information
Molecular Weight 728.77
Formula C29H44O12.8(H2O)
CAS Number 11018-89-6
Solubility (25°C) Water: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Waqas Younis, et al. Role of the NO/cGMP pathway and renin-angiotensin system in the hypotensive and diuretic effects of aqueous soluble fraction from Crataegus songarica K. Koch

[2] Jeffrey Aalders, et al. Assessing Teratogenicity from the Clustering of Abnormal Phenotypes in Individual Zebrafish Larvae

[3] Chun-Ting Su, et al. Anti-HSV activity of digitoxin and its possible mechanisms

[4] A B Forrest, et al. Testing for circadian differences in lethality for intravenous ouabain in male mice

[5] R G Carpentier, et al. Cocaine suppression of triggered activity. A possible mechanism of antiarrhythmic action

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Keywords: Ouabain octahydrate, Acocantherine; G-Strophanthin supplier, inhibitors, activators


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