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Ouabain Octahydrate is an inhibitor of Na+/K+-ATPase, used for the treatment of congestive heart failure. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity. Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD.
In vivo, Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS.
| Molecular Weight | 728.77 |
| Formula | C29H44O12.8(H2O) |
| CAS Number | 11018-89-6 |
| Solubility (25°C) | Water: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Chun-Ting Su, et al. Anti-HSV activity of digitoxin and its possible mechanisms
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