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Oteseconazole

Cat. No. M10444
Oteseconazole Structure
Synonym:

VT-1161

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 360  USD360 In stock
50mg USD 960  USD960 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Oteseconazole (VT-1161) is an antifungal compound with oral activity that is highly selective for CYP51. It can effectively bind to and inhibit CYP51 of N. albicans (Kd <39 nM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 527.39
Formula C23H16F7N5O2
CAS Number 1340593-59-0
Purity >98.5%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] E P Garvey, et al. Antimicrob Agents Chemother. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model

[2] A G S Warrilow, et al. Antimicrob Agents Chemother. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme

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