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Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.
| Molecular Weight | 398.41 |
| Formula | C24H16F2N4 |
| CAS Number | 755753-89-0 |
| Solubility (25°C) | 1eq. HCl 19.92 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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