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Org 25935 

Cat. No. M30961

All AbMole products are for research use only, cannot be used for human consumption.

Org 25935  Structure

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Quality Control & Documentation
Biological Activity

Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse.

Chemical Information
Molecular Weight 375.89
Formula C21H26ClNO3
CAS Number 949588-40-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Andrea de Bejczy, et al. Alcohol Clin Exp Res. Efficacy and safety of the glycine transporter-1 inhibitor org 25935 for the prevention of relapse in alcohol-dependent patients: a randomized, double-blind, placebo-controlled trial

[2] Joep H Schoemaker, et al. J Clin Psychopharmacol. The selective glycine uptake inhibitor org 25935 as an adjunctive treatment to atypical antipsychotics in predominant persistent negative symptoms of schizophrenia: results from the GIANT trial

[3] Kari R Nations, et al. J Clin Psychiatry. Evaluation of the glycine transporter inhibitor Org 25935 as augmentation to cognitive-behavioral therapy for panic disorder: a multicenter, randomized, double-blind, placebo-controlled trial

[4] Helga Höifödt Lidö, et al. Alcohol Clin Exp Res. The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens

[5] Anna Molander, et al. Alcohol Alcohol. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats

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Keywords: Org 25935  supplier, GlyT, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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