About 14 results found for searched term "GlyT" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9372 | Yoda1 | Piezo Channel |
| GlyT2-IN-1; Yoda 1 | ||
| Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). | ||
| M2389 | Amoxapine | Others |
| CL-67772 | ||
| Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM. | ||
| M1500 | Sarcosine | Others |
| N-Methylglycine | ||
| Sarcosine is a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site. | ||
| M5464 | Bitopertin | GlyT |
| RG1678, RO-4917838 | ||
| Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells. | ||
| M6426 | ALX 5407 hydrochloride | Others |
| ALX 5407 hydrochloride is a selective non-transportable GlyT1 inhibitor. | ||
| M6928 | LY 2365109 hydrochloride | GlyT |
| LY 2365109 hcl | ||
| LY 2365109 hydrochloride is a potent and selective GlyT1 inhibitor. | ||
| M7025 | NFPS | Others |
| NFPS is a selective non-transportable GlyT1 inhibitor. | ||
| M7088 | Org 24598 lithium salt | Others |
| Org 24598 lithium salt is a selective GlyT1 inhibitor. | ||
| M7089 | Org 25543 hydrochloride | Others |
| Org 25543 hydrochloride is a potent and selective GlyT2 inhibitor. | ||
| M21103 | Iclepertin | Others |
| BI-425809 | ||
| Iclepertin (BI 425809) is an oral glycine transporter-1 (GlyT1) inhibitor being developed for the study of cognitive impairment associated with schizophrenia (CIAS). | ||
| M30010 | ASP2535 | GlyT |
| ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease. | ||
| M30961 | Org 25935 | GlyT |
| Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse. | ||
| M55411 | N-Arachidonylglycine | Metabolite/Endogenous Metabolite |
| NAGLY; NA-Gly | ||
| N-Arachidonylglycine (NA-Gly) is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration. | ||
| M56491 | ALX-1393 | GlyT |
| ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model. | ||
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