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Orelabrutinib

Cat. No. M10095
Orelabrutinib Structure
Synonym:

ICP-022

Size Price Availability Quantity
5mg USD 250.2  USD278 In stock
10mg USD 350.1  USD389 In stock
50mg USD 914.4  USD1016 In stock
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Quality Control
Biological Activity

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 427.49
Formula C26H25N3O3
CAS Number 1655504-04-3
Purity 99.31%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

Orelabrutinib: First Approval
Sohita Dhillon. Drυgs. 2021 Mar;81(4):503-507. PMID: 33704654.

Current Role and Emerging Evidence for Bruton Tyrosine Kinase Inhibitors in the Treatment of Mantle Cell Lymphoma
David A Bond, et al. Hematol Oncol Clin North Am. 2020 Oct;34(5):903-921. PMID: 32861286.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Orelabrutinib, ICP-022 supplier, BTK, inhibitors

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