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ONO-4059 analogue

Cat. No. M5162

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ONO-4059 analogue Structure
Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 180  USD180 In stock
50mg USD 590  USD590 In stock
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Quality Control & Documentation
Biological Activity

ONO-4059 analogue is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with IC50 of 23.9 nM. ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis in TMD-8 cells. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.

Chemical Information
Molecular Weight 456.5
Formula C25H24N6O3
CAS Number 1351635-67-0
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yasuhiro T, et al. Blood. ONO-4059, A Novel Bruton’s Tyrosine Kinase (Btk) Inhibitor: Synergistic Activity In Combination With Chemotherapy In a ABC-DLBCL Cell Line.

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Keywords: ONO-4059 analogue supplier, BTK, inhibitors, activators

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