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ONO-4059 analogue

Cat. No. M5162
ONO-4059 analogue Structure
Size Price Availability Quantity
5mg USD 99  USD110 In stock
10mg USD 162  USD180 In stock
50mg USD 495  USD550 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ONO-4059 analogue is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with IC50 of 23.9 nM. ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis in TMD-8 cells. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 456.5
Formula C25H24N6O3
CAS Number 1351635-67-0
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

ONO-4059, A Novel Bruton’s Tyrosine Kinase (Btk) Inhibitor: Synergistic Activity In Combination With Chemotherapy In a ABC-DLBCL Cell Line.
Yasuhiro T, et al. Blood. 2013;122:5151.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ONO-4059 analogue supplier, BTK, inhibitors

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