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ONC206

Cat. No. M20979
ONC206 Structure
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Biological Activity

ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity.

Chemical Information
Molecular Weight 408.44
Formula C23H22F2N4O
CAS Number 1638178-87-6
Solubility (25°C) DMSO 82 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Justyna M Przystal, et al. Neuro Oncol. Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

[2] Yingao Zhang, et al. Front Oncol. ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro

[3] Jennifer C Goodell, et al. J Pharm Biomed Anal. Quantitation of the next-generation imipridone ONC206 in human plasma by a simple and sensitive UPLC-MS/MS assay for clinical pharmacokinetic application

[4] Benjamin Purow. Neuro Oncol. ONC201 and ONC206: Metabolically ClipPing the wings of diffuse midline glioma

[5] Katherine Tucker, et al. Am J Cancer Res. ONC206 has anti-tumorigenic effects in human ovarian cancer cells and in a transgenic mouse model of high-grade serous ovarian cancer

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