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Olodaterol

Cat. No. M5245
Olodaterol Structure
Synonym:

BI1744

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 160  USD160 In stock
25mg USD 350  USD350 In stock
50mg USD 520  USD520 In stock
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Quality Control & Documentation
Biological Activity

Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.

In Vitro: Olodaterol shows a potent, nearly full agonistic response at the hβ2-adrenoceptor (EC50=0.1 nM; intrinsic activity=88% compared with isoprenaline) and a significant selectivity profile (241- and 2299-fold against the hβ1- and hβ3-ARs, respectively).

In Vivo: Olodaterol is a long acting β2-agonist, Olodaterol dose-dependently attenuates cell influx and pro-inflammatory mediator release in murine and guinea pig models of pulmonary inflammation.

Chemical Information
Molecular Weight 370.44
Formula C21H26N2O5
CAS Number 868049-49-4
Solubility (25°C) Water 5 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ramadan WH, et al. Am J Health Syst Pharm. Olodaterol for the treatment of chronic obstructive pulmonary disease.

[2] Wex E, et al. Br J Pharmacol. The long-acting β2 -adrenoceptor agonist olodaterol attenuates pulmonary inflammation.

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Keywords: Olodaterol, BI1744 supplier, Adrenergic Receptor, inhibitors, activators


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