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Ofatumumab is a humanised anti-CD20 monoclonal antibody whose epitope is distinct from that of rituximab. The CD20 antigen is expressed on solely B cell lymphocytes. Compared with rituximab, ofatumumab binds more tightly to CD20 with a slower off-rate. Ofatumumab causes cytotoxicity in the cells that express CD20 by means of complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC).
| Molecular Weight | 146059.83 |
| Formula | C6480H10022N1742O2020S44 |
| CAS Number | 679818-59-8 |
| Form | Liquid |
| Storage | -80°C for long term |
[1] Lin TS, et al. Pharmgenomics Pers Med. Ofatumumab: a novel monoclonal anti-CD20 antibody.
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