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OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1
on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
| Molecular Weight | 440.31 |
| Formula | C17H18BrN3O4S |
| CAS Number | 919973-83-4 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Won-Gune Jeong, et al. Removal of 1,2-dichloroethane in groundwater using Fenton oxidation
[2] Bas C Stunnenberg, et al. N-of-1 Trials in Neurology: A Systematic Review
[3] Wanying He, et al. Status of N-of-1 Trials in Chronic Pain Management: A Narrative Review
[4] Suzanne McDonald, et al. N-of-1 Trials in Healthcare
[5] E Mordijck, et al. N-of-1 trials in child and adolescent psychiatry: a closer look at stimulants
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