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Oclacitinib is a novel JAK inhibitor with IC50 value of 10 nM for JAK1. Oclacitinib inhibits JAK1, JAK2, JAK3, and TYK2 with IC50 values of 10, 18, 99, and 84 nM, respectively. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 values ranging from 36 to 249 nM.
Patent. RU2812575C2 2024 Jan 30.
Patent. RU2812575C2
Oclacitinib purchased from AbMole
Patent. AU2019426113B2 2022 Jun 16.
Patent. AU2019426113B2
Oclacitinib purchased from AbMole
| Molecular Weight | 337.44 |
| Formula | C15H23N5O2S |
| CAS Number | 1208319-26-9 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related JAK Products |
|---|
| iJak-381
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. |
| Ritlecitinib (malonate)
Ritlecitinib (PF-06651600) malonate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. |
| Deuruxolitinib
Deuruxolitinib is a deuterated Ruxolitinib (INCB18424), which modulates the activity of JAK1/JAK2. Deuruxolitinib can be used for the research of hair loss disorders. |
| A-005
A-005 is a potentially first-in-class, brain-penetrating TYK2 allosteric inhibitor for studies related to neuroinflammatory and neurodegenerative diseases. |
| Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2. |
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Products are for research use only. Not for human use. We do not sell to patients.
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