Free shipping on all orders over $ 500

NVP-BSK805 dihydrochloride

Cat. No. M1804
NVP-BSK805 dihydrochloride Structure

NVP-BSK805, BSK805 2HCl

Size Price Availability
10mM*1mL in DMSO USD 216  USD216 1-2 Weeks
5mg USD 175  USD175 1-2 Weeks
10mg USD 262  USD262 1-2 Weeks
25mg USD 440  USD440 1-2 Weeks
50mg USD 750  USD750 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

NVP-BSK805 dihydrochloride is a potent and selective quinoxaline JAK2 inhibitor with IC50 values of 0.48, 0.56 and 0.58 nM for JAK2 JH1, FL JAK V617F and FL JAK2 wt respectively. Within the JAK family, NVP-BSK805 displays more than 20-fold selectivity towards JAK2 in vitro, as well as excellent selectivity in broader kinase profiling. The compound blunts constitutive STAT5 phosphorylation in JAK2(V617F)-bearing cells, with concomitant suppression of cell proliferation and induction of apoptosis. In vivo, NVP-BSK805 exhibited good oral bioavailability and a long half-life. The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba/F3 JAK2(V617F) cell-driven mouse mechanistic model. Furthermore, NVP-BSK805 potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

Customer Product Validations & Biological Datas
Source Acta Haematol (2014). Figure 4. NVP-BSK805
Method Western blot
Cell Lines SET-2 and HEL cell line
Concentrations 0.01, 0.05, 0.1, 0.5, 1.0 μM
Incubation Time 24 h
Results The JAK2-positive cell line SET-2 showed suppression of STAT5a phosphorylation already at a concentration of 0.1 μ M of NVP-BSK805 and NVP-BVB808, whereas in HEL cells higher concentrations
Chemical Information
Molecular Weight 563.47
Formula C27H28F2N6O.2HCl
CAS Number 1942919-79-0
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related JAK Products

Londamocitinib is a potent and selective JAK1 inhibitor with anti-inflammatory activity.

SJ1008030 TFA

SJ1008030 TFA is a JAK2 PROTAC which selectively degrades JAK2.


DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand.


STAT3-IN-18 is a platinum (IV) complex with an axial ligand derived from sandalwood.


JAK-IN-28 is a JAK inhibitor.

Abmole Inhibitor Catalog

Keywords: NVP-BSK805 dihydrochloride, NVP-BSK805, BSK805 2HCl supplier, JAK, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.