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Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent.
| Molecular Weight | 360.04 |
| CAS Number | 2095732-06-0 (free base) |
| Solubility (25°C) | DMSO 55 mg/mL Water 37.78 mg/mL |
| Storage | -20°C, dry, sealed |
[1] Jonathan Wolf Mueller, et al. Steroid Sulfation in Adrenal Tumors
[2] Thomas Alec Lightning, et al. Steroid disulfates - Sulfation double trouble
[3] Zhengxiong Zhou, et al. [Production and application of 3-phosphoadenosine-5- phosphosulfate]
[4] Christine Kaufmann, et al. Sulfated plant peptide hormones
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