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Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.
| Molecular Weight | 426.85 |
| Formula | C21H19ClN4O4 |
| CAS Number | 341001-38-5 |
| Solubility (25°C) | DMSO: ≥15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Bo Pang, et al. Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites
[5] Richard Y Kao, et al. Identification of influenza A nucleoprotein as an antiviral target
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