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Nucleozin

Cat. No. M7955

All AbMole products are for research use only, cannot be used for human consumption.

Nucleozin Structure

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Quality Control & Documentation
Biological Activity

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.

Chemical Information
Molecular Weight 426.85
Formula C21H19ClN4O4
CAS Number 341001-38-5
Solubility (25°C) DMSO: ≥15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bo Pang, et al. Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites

[2] Meng-I Lin, et al. Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1

[3] Maria Joao Amorim, et al. Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection

[4] Hui-Chen Hung, et al. Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching

[5] Richard Y Kao, et al. Identification of influenza A nucleoprotein as an antiviral target

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Keywords: Nucleozin supplier, inhibitors, activators

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