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Nucleocidin

Cat. No. M29671
Nucleocidin Structure
Synonym:

4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007

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Biological Activity

Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

Chemical Information
Molecular Weight 364.31
Formula C10H13FN6O6S
CAS Number 24751-69-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Phillip T Lowe, et al. Chem Soc Rev. 4'-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics

[2] A R Ola Pasternak, et al. Chembiochem. Identification of Genes Essential for Sulfamate and Fluorine Incorporation During Nucleocidin Biosynthesis

[3] Xuan Feng, et al. RSC Adv. Isolation of 5'- O-sulfamyladenosine and related 3'- O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

[4] Xuan Feng, et al. Chem Sci. Two 3'- O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus

[5] Xi Ming Zhu, et al. Chembiochem. Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule

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Keywords: Nucleocidin, 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007 supplier, Antibiotic, inhibitors, activators

 
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