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NU6102 

Cat. No. M30106

All AbMole products are for research use only, cannot be used for human consumption.

NU6102  Structure
Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 110  USD110 In stock
10mg USD 165  USD165 In stock
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Quality Control & Documentation
Biological Activity

NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2 over CDK4 (IC50 of 1.6 μM), DYRK1A (IC50 of 0.9 μM), PDK1 (IC50 of 0.8 μM) and ROCKII (IC50 of 0.6 μM).

Chemical Information
Molecular Weight 402.47
Formula C18H22N6O3S
CAS Number 444722-95-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Theodosia Teo, et al. Pharmacol Res. An overview of CDK3 in cancer: clinical significance and pharmacological implications

[2] Lindsey S Treviño, et al. Mol Endocrinol. Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK

[3] Elizabeth Anscombe, et al. Chem Biol. Identification and Characterization of an Irreversible Inhibitor of CDK2

[4] Huw D Thomas, et al. Eur J Cancer. Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301

[5] N Johnson, et al. Br J Cancer. Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells

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  Catalog
Abmole Inhibitor Catalog




Keywords: NU6102  supplier, CDK, inhibitors, activators

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