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NSI-189

Cat. No. M2589

All AbMole products are for research use only, cannot be used for human consumption.

NSI-189 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 44  USD44 In stock
5mg USD 40  USD40 In stock
10mg USD 68  USD68 In stock
50mg USD 242  USD242 In stock
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Quality Control & Documentation
Biological Activity

NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo.When in vitro,The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation.In vivo,NSI-189 increases the hippocampal volume of healthy adult mice by 20%.

Customer Product Validations & Biological Datas
Source Radiat Res (2018). Figure 6. NSI-189
Method i.e.
Cell Lines Rat
Concentrations 30 mg/kg
Incubation Time five weeks
Results Importantly, this radiation-induced deficit was ameliorated significantly by NSI-189 treatment, resulting in an increase (55%) of dual stained granule cell neurons compared to the irradiated cohort
Chemical Information
Molecular Weight 366.5
Formula C22H30N4O
CAS Number 1270138-40-3
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Karl K Johe, et al. NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder

[2] G I Papakostas, et al. A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder

[3] Yan Liu, et al. Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189

[4] Roger S McIntyre, et al. The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects

[5] Naoki Tajiri, et al. NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats

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