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NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo.When in vitro，The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation.In vivo，NSI-189 increases the hippocampal volume of healthy adult mice by 20%.
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Source | Radiat Res (2018). Figure 6. NSI-189 |
| Method | i.e. | |
| Cell Lines | Rat | |
| Concentrations | 30 mg/kg | |
| Incubation Time | five weeks | |
| Results | Importantly, this radiation-induced deficit was ameliorated significantly by NSI-189 treatment, resulting in an increase (55%) of dual stained granule cell neurons compared to the irradiated cohort |
| Molecular Weight | 366.5 |
| Formula | C22H30N4O |
| CAS Number | 1270138-40-3 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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