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Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity.
Novobiocin (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90. Novobiocin (200 µM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.
Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.
| Molecular Weight | 612.62 |
| Formula | C31H36N2O11 |
| CAS Number | 303-81-1 |
| Solubility (25°C) | DMSO 31 mg/mL |
| Storage | -20°C, dry, sealed |
[1] Angelika Dlugosz, et al. Mini Rev Med Chem. Novobiocin Analogs as Potential Anticancer Agents
[3] H HOEKSEMA, et al. Prog Ind Microbiol. Novobiocin
[4] No authors listed. Q Rev Pediatr. NOVOBIOCIN
[5] H D Riley Jr. Med Clin North Am. Vancomycin and novobiocin
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
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