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Norepinephrine hydrochloride

Cat. No. M13896
Norepinephrine hydrochloride Structure

Levarterenol hydrochloride; L-Noradrenaline hydrochloride

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Biological Activity

Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.

Chemical Information
Molecular Weight 205.64
CAS Number 329-56-6
Solubility (25°C) Water 90 mg/mL
DMSO 44 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] T Yadav, et al. Structural confirmation and spectroscopic study of a biomolecule: Norepinephrine

[2] Maedeh Ghasemi, et al. Mechanisms underlying anticonvulsant and proconvulsant actions of norepinephrine

[3] May T Aziz, et al. Serotonin-norepinephrine reuptake inhibitors for the management of chemotherapy-induced peripheral neuropathy

[4] Eliyahu Dremencov, et al. Brain norepinephrine system as a target for antidepressant and mood stabilizing medications

[5] N Weiner. Regulation of norepinephrine biosynthesis

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Keywords: Norepinephrine hydrochloride, Levarterenol hydrochloride; L-Noradrenaline hydrochloride supplier, Adrenergic Receptor, inhibitors, activators

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