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Nonacog alfa

Cat. No. M24819
Nonacog alfa Structure
Synonym:

BAX326; Coagulation Factor IX

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Biological Activity

Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B.

Chemical Information
CAS Number 181054-95-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Brigitte Tardy, et al. Haemophilia. Revised terminal half-life of nonacog alfa as derived from extended sampling data: A real-world study involving 64 haemophilia B patients on nonacog alfa regular prophylaxis

[2] Maria Elisa Mancuso, et al. Lancet. The changing treatment landscape in haemophilia: from standard half-life clotting factor concentrates to gene editing

[3] Ri Liesner, et al. Haemophilia. Safety and efficacy of nonacog alfa for the treatment of haemophilia B in children younger than 6 years of age in a routine clinical care setting: the EUREKIX registry study

[4] Yvonne Brennan, et al. Expert Opin Biol Ther. Trenonacog alfa for prophylaxis, on-demand and perioperative management of hemophilia B

[5] Pablo Rendo, et al. Blood Coagul Fibrinolysis. Nonacog alfa: an analysis of safety data from six prospective clinical studies in different patient populations with haemophilia B treated with different therapeutic modalities

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Keywords: Nonacog alfa, BAX326; Coagulation Factor IX supplier, inhibitors, activators

 
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