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NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure.
| Molecular Weight | 207.23 |
| Formula | C10H13N3O2 |
| CAS Number | 64091-91-4 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 62.5 mg/mL |
| Storage | Powder -20°C |
[2] Marissa E Di, et al. Methods Cell Biol. Lung carcinomas induced by NNK and LPS
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