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Nn-dnj is a glucosidase inhibitor that acts as a compound chaperone. Nn-dnj also acts synergistically with protein balance regulators such as Celastrol and MG132 to stabilize the mutant protein in a properly folded state. Nn-dnj stabilizes various proteins to prevent misfolding and increase normal transport of endoplasmic reticulum. It has potential uses in studying diseases marked by misfolded proteins and showing antiviral activity.
| Molecular Weight | 289.41 |
| Formula | C15H31NO4 |
| CAS Number | 81117-35-3 |
| Solubility (25°C) | DMSO: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Ulrika Andersson, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo
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