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NN-DNJ

Cat. No. M7967

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NN-DNJ Structure

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Quality Control & Documentation
Biological Activity

Nn-dnj is a glucosidase inhibitor that acts as a compound chaperone. Nn-dnj also acts synergistically with protein balance regulators such as Celastrol and MG132 to stabilize the mutant protein in a properly folded state. Nn-dnj stabilizes various proteins to prevent misfolding and increase normal transport of endoplasmic reticulum. It has potential uses in studying diseases marked by misfolded proteins and showing antiviral activity.

Chemical Information
Molecular Weight 289.41
Formula C15H31NO4
CAS Number 81117-35-3
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] D Thirumal Kumar, et al. A comparative computational approach toward pharmacological chaperones (NN-DNJ and ambroxol) on N370S and L444P mutations causing Gaucher's disease

[2] Marina Katzman Ya'kobovitz, et al. Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders

[3] Liang Yu, et al. Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease

[4] Ulrika Andersson, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo

[5] Anand Mehta, et al. Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ

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Keywords: NN-DNJ supplier, inhibitors, activators

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