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Nn-dnj is a glucosidase inhibitor that acts as a compound chaperone. Nn-dnj also acts synergistically with protein balance regulators such as Celastrol and MG132 to stabilize the mutant protein in a properly folded state. Nn-dnj stabilizes various proteins to prevent misfolding and increase normal transport of endoplasmic reticulum. It has potential uses in studying diseases marked by misfolded proteins and showing antiviral activity.
Molecular Weight | 289.41 |
Formula | C15H31NO4 |
CAS Number | 81117-35-3 |
Solubility (25°C) | DMSO: ≥10 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Ulrika Andersson, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo
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