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Nilotinib hydrochloride

Cat. No. M20466

All AbMole products are for research use only, cannot be used for human consumption.

Nilotinib hydrochloride Structure
Synonym:

AMN-107 HCl

Price and Availability

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Quality Control & Documentation
Biological Activity

Nilotinib hydrochloride is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

Chemical Information
Molecular Weight 565.98
Formula C28H23ClF3N7O
CAS Number 923288-95-3
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jieun Kim, et al. J Neuroinflammation. Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling

[2] Fernando L Pagan, et al. Mov Disord. Long-Term Safety and Clinical Effects of Nilotinib in Parkinson's Disease

[3] Martin Gresse, et al. Recent Results Cancer Res. Nilotinib

[4] Benjamin N Ostendorf, et al. Recent Results Cancer Res. Nilotinib

[5] Giuseppe Saglio, et al. N Engl J Med. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia

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Keywords: Nilotinib hydrochloride, AMN-107 HCl supplier, Src-bcr-Abl, inhibitors, activators

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