Nikethamide is a respiratory center activator that can increase the sensitivity of the respiratory center to carbon dioxide by exciting the respiratory center in the medulla oblongata or by stimulating the chemoreceptors in the carotid sinus and the aortic body and reflexively excites the respiratory center, and can be used in studies related to respiratory failure.
| Molecular Weight | 178.23 |
| Formula | C10H14N2O |
| CAS Number | 59-26-7 |
| Form | Liquid |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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