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NIDA-41020

Cat. No. M7970

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NIDA-41020 Structure

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Quality Control & Documentation
Biological Activity

NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].

Chemical Information
Molecular Weight 459.37
Formula C23H24Cl2N4O2
CAS Number 502486-89-7
Solubility (25°C) DMSO: ~16 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ismail Nurul Iman, et al. Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB 1 Receptor Antagonism

[2] Rita Citraro, et al. Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice

[3] B J Venhuis, et al. The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the internet

[4] Dennis K Miller, et al. Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity

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